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Larkina Tatyana Aleksandrovna
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ALLELIC VARIANTS AND EXPRESSION CANDIDATE GENES FOR ABDOMINAL FATMASS IN CHICKENS
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The expression of nine candidate genes for QTL abdominal fat weight and relative abdominal fat content was investigated by real-time polymerase chain reaction (PCR) in the liver, adipose tissue, colon, muscle, pituitary gland and brain of broilers. The high mobility group AT hook1 (HMG1A) gene was up-regulated in liver with aratio of means of 2,90 (P≤0,01) in the «fatty» group (relative abdominal fat content 3,5±0.18%, abdominal fat weight 35,4±6,09 g) relative to the «lean» group (relative abdominal fat content 1,9±0,56%, abdominal fat weight 19,2±5,06 g). Expression of this gene was highly correlated with the relative abdominal fat content (0,70, P≤0,01) and abdominal fat weight (0,70, P≤0,01). The peroxisomeproliferator-activated receptor gamma (PPARG) gene was also up-regulated in the liver with a ratio of means of 3,34(P≤0,01) in the «fatty» group relative to the «lean» group. Correlation of its expression was significant with both the relative abdominal fat content (0,55, P≤0,05) and the abdominal fat weight (0,57, P≤0,01). These data obtained and the data of references will allow the statement that the HMG1A, PPARG and FABP2 genes were candidate genes for abdominal fat deposition in chickens. Searching of rSNPs in regulatory regions of thesegenes could provide a tool for gene-assisted selection
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