name
Piven Aleksandr Vladimirovich
Scholastic degree
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Academic rank
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Honorary rank
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Organization, job position
• Children's city clinical hospital №1
Отделение клеточных и репродуктивных технологий
биолог
Research interests
Web site url
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TOP5 co-authors
Articles count: 2
Сформировать список работ, опубликованных в Научном журнале КубГАУ
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Description
The research shows the possibility of extended preimplantation genetic screening (PGD) that allows to improve the strategy of selection of embryos that satisfies not only the requirement of the absence of chromosomal abnormalities, but also includes their additional check for predisposition to various diseases, as well as the choice of the embryo with the most optimal HLA haplotype in cases with expressed compatibility of parents for HLA-genes
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Description
Isolation of fetal cells from the blood of a pregnant woman is more relevant for receiving the information of the genome of a fetus and implementation in clinical practice, non-invasive screening methods for prenatal diagnosis. The work proposes efficient ways of sorting trophoblasts circulating in maternal blood for the diagnosis of fetal aneuploidy in early gestation by analyzing microsatellite marker of the chromosomes that most prone to numerical aberrations (13, 18, 21, X and Y). A set of microsatellite markers allowed to reveal aneuploidy in three pregnant women, and also to exclude mosaicism and contamination of samples with maternal cells. A retrospective analysis of data on invasive cytogenetic studies (chorionic villus sampling) confirmed the results of the study
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