Kuban State Medical University
Author list of organization
List of articles written by the authors of the organization
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VISUALIZATION OF NEURONAL ACTIVITY IN FROG’S VAGO-SYMPATHETIC TRUNK
Description
It is proposed to use the visualization method of propagation of excitation in the nerve in a highfrequency electric field
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Description
The research shows the possibility of extended preimplantation genetic screening (PGD) that allows to improve the strategy of selection of embryos that satisfies not only the requirement of the absence of chromosomal abnormalities, but also includes their additional check for predisposition to various diseases, as well as the choice of the embryo with the most optimal HLA haplotype in cases with expressed compatibility of parents for HLA-genes
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SECONDARY IMMUNODEFICIENCIES OF SMALL PETS AND THEIR CORRECTION USING MURAMYLDIPEPTIDE
Description
The revolutionary discoveries of recent years in immunology has proved that protection from infections and biological aggression leading role played by innate immunity, which leads to the launch and subsequent work of specific adaptive immunity. Today, it is well-known that almost any pathology of the animal affects the immune system and creates an immune imbalance, leading to development of chronic pathological process, frequent relapses and to the development of different kind of complications. Secondary immunodeficiency states are widely distributed and differ in many etiological factors age, nutritional, medicinal, infectious and neoplastic nature, which leads to increased susceptibility of animal to various раthogenic factors, the weakening of the body. Awareness of the role of immunological disorders in the pathogenesis of a number of diseases has led to the need use in veterinary medicines that are aimed to influence on the immune system of the animal at the known molecular mechanism, to combine safety with high clinical efficacy. In this respect, a promising immunomodulators of microbial origin, due to the knowledge of the recognition mechanisms of the innate immune system such as bacteria as a whole, separate structural units, including mini-optimal biologically active fragments. This review is dedicated to one of the immunomodulator of microbial origin – which is an analog of biologically active fragment of muramyldipeptide of bacterial cell walls ‒ glucosaminylmuramildipeptide (GMDP), which is the active substance of registrated in Russia drug with the trade name Glicopin for use in veterinary practice. The drug showed high efficiency when used in cats, dogs, rodents, ferrets with infections of bacterial and viral etiology; cancer; with the aim of improving the natural resistance of the organism of young and old animals; enhance the effectiveness of vaccination in immunocompromised animals; postvaccine reduce complications; reduce stress financial position, such as during transportation and various veterinary treatments; injuries and on-line intervention (for stimulation of repair processes and tissue regeneration); prevention of immunodeficiency in newborn animals; the reduction of postpartum involutional processes in the uterus. Analysis of literature data allows us to consider an important outcome of immunologiс discoveries of recent years is the change of views on the question of the treatment of infectious diseases and the role of drugs as activators of innate immunity, among which an important role is played by a synthetic analogue of muramyldipeptide (GMDP) is a drug with a known molecular mechanism of action
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SELECTION OF FETAL CELLS CIRCULATING IN MATERNAL BLOOD FOR NONINVASIVE PRENATAL DIAGNOSIS
Description
Trophoblast cells circulating in maternal blood may serve as potential sources of genetic information for screening in obstetric practice approaches to noninvasive prenatal diagnosis. The material for the study was whole blood of pregnant women of gestational ages of 8-12 weeks in a volume of 10 ml. stabilized with heparin. Enrichment was performed by the method of gradient centrifugation and magnetic separation (CD45–) with fluorescent staining negative fractions labeled with antibodies to antigens of trophoblasts (HLA-G, and Trop-2) to conduct flow cytometry and sorting of cells on glass slides. Single cell candidates using laser micro dissection were transferred into a vial for subsequent whole-genome amplification, providing sufficient representativeness of their genome. Fetal origin of the genetic material was confirmed by comparison of alleles of the HLA genes of the parents and cells candidates. It is possible to improve significantly the accuracy and versatility of non-invasive prenatal diagnosis using comparative genomic hybridization using chips (аCGH)
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Description
Via the method of visualizing the excitation in the high frequency field there were discovered the efferent signals in the frog medulla oblongata, which were related to the heart rhythm
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There is gender differences regulatory-adaptive status of the students at the beginning and at the end of the academic year in the article. The results must be considered in the allocation of training load during the academic year
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In this article we have listed the data concerning the influence of the respiration depth on the parameters of the cardiopulmonary synchronism depending on the personality type
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The article shows that via the dynamics of the regulatory adaptive status it is possible to asses the effectiveness of the treatment for the patients with angina pectoris (third functional class)
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Description
In the high frequency electric field we have revealed afferent signals in the frog medulla oblongata for learning the heart vago - sympathetic trunk rhythm
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THE OPERATED EYE HYDRODYNAMICS MATHEMATICAL MODELING FOR OPTIMIZATION OF SURGERY THECNIQUE
Description
Acceptable values of the drainage hole parameters in the shunt glaucoma surgery were calculated by means of mathematical modeling of different conditions of eye hydrodynamics. The operation method was designed with provision for pressure gradient, rate of the aqueous humor outflow, and the values of intraocular pressure in early and late postoperative period. The balance of liquid in eye was calculated in mathematical model as ordinary differential equation in accordance with flow resistance of every section. The data received by using mathematical model has shown that allowable rate of aqueous humor outflow is gained with the hole diameter of 0,025 mm. This mathematical model should assist to the better understanding of physical processes describing the eye hydrodynamics, should benefit to the operation quality and should create the base to the clinical studies
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