Kuban State Medical University
Author list of organization
List of articles written by the authors of the organization
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THE ASSESSMENT OF THREATENED MISCARRIAGE USING REGULATIONADAPTIVE STATUS
DescriptionThe index definition of regulatory-adaptive status in women with the threat of termination of pregnancy in the first trimester is a highly predictor of pregnancy outcome and should be used in obstetric hospitals and antenatal clinics
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Description
Via the method of visualizing the excitation in the high frequency field there were discovered the efferent signals in the frog medulla oblongata, which were related to the heart rhythm
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PREDICTION OF ADAPTATION OF PATIENTS TO FIXED TEETH USING REGULATORYADAPTIVE STATUS RATE
DescriptionUsing the of rate regulatory-adaptive status we can make a prediction for adaptation of patients to fixed teeth
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Description
In this article we have listed the data concerning the influence of the respiration depth on the parameters of the cardiopulmonary synchronism depending on the personality type
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Description
In the high frequency electric field we have revealed afferent signals in the frog medulla oblongata for learning the heart vago - sympathetic trunk rhythm
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SECONDARY IMMUNODEFICIENCIES OF SMALL PETS AND THEIR CORRECTION USING MURAMYLDIPEPTIDE
DescriptionThe revolutionary discoveries of recent years in immunology has proved that protection from infections and biological aggression leading role played by innate immunity, which leads to the launch and subsequent work of specific adaptive immunity. Today, it is well-known that almost any pathology of the animal affects the immune system and creates an immune imbalance, leading to development of chronic pathological process, frequent relapses and to the development of different kind of complications. Secondary immunodeficiency states are widely distributed and differ in many etiological factors age, nutritional, medicinal, infectious and neoplastic nature, which leads to increased susceptibility of animal to various раthogenic factors, the weakening of the body. Awareness of the role of immunological disorders in the pathogenesis of a number of diseases has led to the need use in veterinary medicines that are aimed to influence on the immune system of the animal at the known molecular mechanism, to combine safety with high clinical efficacy. In this respect, a promising immunomodulators of microbial origin, due to the knowledge of the recognition mechanisms of the innate immune system such as bacteria as a whole, separate structural units, including mini-optimal biologically active fragments. This review is dedicated to one of the immunomodulator of microbial origin – which is an analog of biologically active fragment of muramyldipeptide of bacterial cell walls ‒ glucosaminylmuramildipeptide (GMDP), which is the active substance of registrated in Russia drug with the trade name Glicopin for use in veterinary practice. The drug showed high efficiency when used in cats, dogs, rodents, ferrets with infections of bacterial and viral etiology; cancer; with the aim of improving the natural resistance of the organism of young and old animals; enhance the effectiveness of vaccination in immunocompromised animals; postvaccine reduce complications; reduce stress financial position, such as during transportation and various veterinary treatments; injuries and on-line intervention (for stimulation of repair processes and tissue regeneration); prevention of immunodeficiency in newborn animals; the reduction of postpartum involutional processes in the uterus. Analysis of literature data allows us to consider an important outcome of immunologiс discoveries of recent years is the change of views on the question of the treatment of infectious diseases and the role of drugs as activators of innate immunity, among which an important role is played by a synthetic analogue of muramyldipeptide (GMDP) is a drug with a known molecular mechanism of action
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SELECTION OF FETAL CELLS CIRCULATING IN MATERNAL BLOOD FOR NONINVASIVE PRENATAL DIAGNOSIS
DescriptionTrophoblast cells circulating in maternal blood may serve as potential sources of genetic information for screening in obstetric practice approaches to noninvasive prenatal diagnosis. The material for the study was whole blood of pregnant women of gestational ages of 8-12 weeks in a volume of 10 ml. stabilized with heparin. Enrichment was performed by the method of gradient centrifugation and magnetic separation (CD45–) with fluorescent staining negative fractions labeled with antibodies to antigens of trophoblasts (HLA-G, and Trop-2) to conduct flow cytometry and sorting of cells on glass slides. Single cell candidates using laser micro dissection were transferred into a vial for subsequent whole-genome amplification, providing sufficient representativeness of their genome. Fetal origin of the genetic material was confirmed by comparison of alleles of the HLA genes of the parents and cells candidates. It is possible to improve significantly the accuracy and versatility of non-invasive prenatal diagnosis using comparative genomic hybridization using chips (аCGH)
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Description
One of the reasons extensions acute intestinal diseases in newborn calves and piglets is absence at them of formed immune system and colonization resistance. For this reason, their intestine often occupies relative pathogenic microorganisms, which in the subsequent cause diarrheal diseases. The characteristic feature of the last time is the fact that these diseases have the associated disposition and composition of association can be the most various but not only biological objects (for calves and piglets), and also territorial borders. The goal of this work was in comparative study of the structure microorganisms, which were isolated from newborn calves and piglets at acute intestinal diseases in Krasnodar territory and the establishment of the dominant species. During the bacteriologic examination of pathological material was detach and finger 1299 isolate calves and 476 from piglets which was found to belonged to 6 families: Enterobacteriaceae, Streptococcaceae, Enterococcaceae, Pseudomonadaceae, Alcaligenaceae, Alteromonadaceae. Studies have shown that dominant logic value in nosological profile of the allocated bacteria belongs to enterobacterium, enterococcus, streptococcus, the share of which in the general pool of isolates has made 70,1%, 15,9% and 11,1%, respectively. At the same time among the enterobacterium detached as from calves, and pigs, the prevailing species was E. coli (55,6%), streptococcus – S. bovis (24,9%), enterococcus – E. faecium and E. faecalis (88,3%). Meanwhile, along with the general character of frequency separation of certain types of bacteria, also their specific preference is set. That why from calves there were more often selected enterobacter, citrobacter, kluyvera, E. faecalis, S. cricetus, S. mitior, S. parauberis and P. aeruginosa. Whereas from pigs more often were allocated protei, providencia, shigella, E. mundtii, E. casseliflavus, S. acidominimus, S. oralis, S. pneumoniae, S. vestibularis и Alcaligenes fecalis than from pigs
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VISUALIZATION OF NEURONAL ACTIVITY IN FROG’S VAGO-SYMPATHETIC TRUNK
DescriptionIt is proposed to use the visualization method of propagation of excitation in the nerve in a highfrequency electric field
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Description
In this article optimum speed diagram of large moving actuating device of АС electric drive with elastic shafting is described. Parameters, conditions of exist-ence and dependence of the duration of the cycle from the angle of rotation of actuating device are defined