14.00.00 Medical sciences
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Description
The aim of the research was to assess the effect of nondrug correction methods of climacteric disorders on the digestive system in patients with metabolic syndrome. 330 women aged 45-50 with the diagnosed metabolic syndrome were examined. Three comparable groups were formed with 110 female patients in each group. In the main group the methods of the nondrug treatment (diet therapy, psychotherapy, physical therapy, exercise therapy) and the vitamin-mineral treatment were combined. In the first control group only the non-drug treatment was used. In the second control group only the vitamin-mineral treatment was used. The female patients’ complaints and the biochemical profile parameters were assessed before the treatment and six months after the treatment. Ultrasound scanning of the abdominal cavity, fibrogastroduodenoscopy and videocolonoscopy were carried out. The results of the study are as follows. In all patients the digestive tract problems were diagnosed at the beginning of the research. Moreover, combined damages were noticedin most of the patients. The main group demonstrated the most pronounced positive dynamic according to the subjective evaluation of the symptoms as to the gastrointestinal tract, as well as according to the parameters of the carbohydrate and fat metabolism. We may conclude that the complex non-drug correction of climacteric disorders in female patients with metabolic syndrome, directed on the increase of the adaptation abilities of thewomen’s organism, the normalization of all kinds of metabolism and of the endocrine profile, has the most important positive effect on the organs of the gastrointestinal tract. This, in its turn, well coordinates all the kinds of metabolism
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Description
Via the method of visualizing the excitation in the high frequency field there were discovered the efferent signals in the frog medulla oblongata, which were related to the heart rhythm
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THE ASSESSMENT OF THREATENED MISCARRIAGE USING REGULATIONADAPTIVE STATUS
Description
The index definition of regulatory-adaptive status in women with the threat of termination of pregnancy in the first trimester is a highly predictor of pregnancy outcome and should be used in obstetric hospitals and antenatal clinics
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Description
In this article we have listed the data concerning the influence of the respiration depth on the parameters of the cardiopulmonary synchronism depending on the personality type
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PREDICTION OF ADAPTATION OF PATIENTS TO FIXED TEETH USING REGULATORYADAPTIVE STATUS RATE
Description
Using the of rate regulatory-adaptive status we can make a prediction for adaptation of patients to fixed teeth
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HIFU: PROSPECTS OF APPLICATION IN ONCOUROLOGY
Description
Prostate cancer (PC) is one of the most frequently malignant neoplasms in the worldwide male population. Back in the 90's began a promising noninvasive method of high-intensity focused ultrasound (HIFU) as an alternative to radical prostatectomy for the treatment of localized prostate cancer was used. Information about the destructive histological effect by HIFU has been known since the 1930, however, the clinical implementation of this technology due to the absence at the time visualization capabilities for monitoring during the procedure has been postponed. In this paper, an overview of published data on the HIFU clinical application in prostate cancer as a major, "saving" and focal therapy. Examples of a favorable combination of this method are also provided with pharmacological agents. Based on the analysis of clinical data, we can say that HIFU is a good alternative minimally invasive therapeutic modality for patients with prostate cancer who are not candidates for radical prostatectomy. Applying of HIFU is possible as a treatment option with local recurrence after external radiotherapy, with careful selection of patients is important, depending on prognostic factors
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CLINICAL AND MORPHOLOGICAL FACTORS AND PREDICTION PARAMETERS OF CELL CYCLE IN ESOPHAGEAL CANCER
Description
The aim of the study is to compare the traditional clinicopathologic factors and prognosis of cell cycle parameters, such as ploidy, cell cycle kinetics, as well as the study of DNA content in the tumor tissue of patients with esophageal cancer. Cancer of the esophagus - a very aggressive malignant disease, most commonly manifested impaired swallowing. As a rule, this type of cancer pathology is characterized by unfavorable outcome. Ploidy and cell proliferation activity, defined by the content of the DNA of the tumor - synthesizing cells are one of the important indicators of the growth rate of malignancy and prognosis. The study was performed on tumor tissue fragments of the 30 patients operated on for cancer of the esophagus. DNA study - conducted in the open cell material aftercare. DNA cell content was determined by flow cytometry BD FACSCanto II. By studying the DNA-cytometric parameters, we found the prevalence of aneuploid tumors in 66.7%. It was shown that DNAcytometric parameters are independent of gender. Major weight of diploid and aneuploid cell tumors of the esophagus was in G0 / 1 phase of the cell cycle. Comparative analysis of DNA - cytometric parameters and the degree of differentiation of esophageal tumor revealed a prevalence of aneuploid tumors in all the test cases. content distribution pattern of tumor cells was found in the G0 / G1-, G2 + M -, S - phase of the cell cycle at different stages of the disease
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SELECTION OF FETAL CELLS CIRCULATING IN MATERNAL BLOOD FOR NONINVASIVE PRENATAL DIAGNOSIS
Description
Trophoblast cells circulating in maternal blood may serve as potential sources of genetic information for screening in obstetric practice approaches to noninvasive prenatal diagnosis. The material for the study was whole blood of pregnant women of gestational ages of 8-12 weeks in a volume of 10 ml. stabilized with heparin. Enrichment was performed by the method of gradient centrifugation and magnetic separation (CD45–) with fluorescent staining negative fractions labeled with antibodies to antigens of trophoblasts (HLA-G, and Trop-2) to conduct flow cytometry and sorting of cells on glass slides. Single cell candidates using laser micro dissection were transferred into a vial for subsequent whole-genome amplification, providing sufficient representativeness of their genome. Fetal origin of the genetic material was confirmed by comparison of alleles of the HLA genes of the parents and cells candidates. It is possible to improve significantly the accuracy and versatility of non-invasive prenatal diagnosis using comparative genomic hybridization using chips (аCGH)
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Description
In the high frequency electric field we have revealed afferent signals in the frog medulla oblongata for learning the heart vago - sympathetic trunk rhythm
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Description
Mortality from malignant diseases is directly linked to early metastasis and relapse. It is now possible to identify individual tumor cells in bone marrow biopsies and peripheral blood. Colorectal cancer is one of the leading places in the structure of cancer incidence and mortality, both in Russia and around the world. Studies have shown that after surgery the ability of tumor cells to the dissemination and implantation increases. The work contains 30 patients with the verified colorectal cancer with metastasis to the liver. To determine the CSC we have applied an analysis technology in CellSearch System ™ (Janssen Diagnostics, LLC). Our study of the number and frequency of detection of circulating tumor cells in peripheral blood of patients and control group demonstrates the reduction in the number of CTCs during laparoscopic surgery and changing the dynamics of the level of tumor cells in the form of reduction from the stage of the mobilization of the drug due to minimally invasive access, minimizing manipulation in the projection of the tumor and as a consequence, preventing the release into the blood stream of single tumor cells
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