16.00.00 Veterinary sciences
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TREATMENT OF CHRONIC ENDOMETRITIS WITH THE NEW DRUG FLORINAZOL
DescriptionIn the article data on spread of chronic endometritises at cows are provided. The microflora range, being in genitals of patients with a chronic endometritis of cows is determined. We have developed a new drug called Florinazol and we also determined his antimicrobic and fungicide activity. Researches on determination of acute and chronic toxicity, and also irritant action on a mucous membrane of a uterus and a vagina are conducted. Researches on studying of influence of Florinazol on blood biochemistry at rabbits are conducted. The optimum therapeutic dose and frequency rate of its introduction is determined. By results of researches it is established that 24,8% of the cows containing on a farm with loose housing content and 10,6% of cows on a farm with fastened content have a chronic endometritis. At the same time in uterus content in 84,3% of cases isolated associations of bacteria and mushrooms in 65,2%, in 34,8% - monocultures of microorganisms. Offered by us means the danger class belongs to substances lowdangerous by the 4th. Doesn't possess irritant action, doesn't exert a negative impact on blood biochemistry, and also has outstanding therapeutic performance of 90% in case of its application in a dose of 100 ml intra-vaginal at an interval of 48 hours
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Description
According to the veterinary reporting on 01.01.2016, presence of a bird in the agricultural organizations and poultry farms makes 13 million 440 thousand heads, in the private sector (hens, geese, ducks, etc.) - 6 million 287 thousand heads. In 2015 in the Krasnodar region 3 million 337 thousand 127 heads were subjected to bacterination against smallpox and a diphtheria. Data on registration of outbreak of smallpox of birds in a private farmstead of the Krasnodar region are presented in article. The case rate and a mortality at hens of breeds of Kulanga and Bramah and pigeons of the Andijan breed are studied. The dermal, diphtheroid and admixed forms of clinical implication of smallpox at hens of different breeds and pigeons in this farmstead are studied. Pathoanathomical features of implication of smallpox of birds are studied. The biological test on chickens of 3-4-month age and a microscopy of the painted smears prints on Pashena is carried out. In smears Pashen's little bodies are found. The events for elimination of a disease in this LTD including rejection of a sick bird, the compelled bacterination at an acquisitive bird, mechanical cleaning and disinfection in a hen house and a dovecot, isolation and a symptomatic treatment of breeding birds are developed and held
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Description
In this study, the authors have defined the acute, subchronic and chronic toxicity of Uritosom preparation, and also its skin-irritating and sensitizing action. The studies that determined the acute toxicity of the drug Uritosom found that remedy which intended for the treatment and prevention of diseases of the genitourinary system with internal method of appointment during the entire observation period did not cause the death and acute toxicity in laboratory animals. In the study of subchronic and chronic toxicity of the drug Uritosom throughout the observation period in both experimental groups death and acute intoxication in animals not registered, also there were no negative phenomena in behavior, reflexes were saved. Consequently, the preparation according to the degree of impact on the body of warm-blooded animals refers to low-hazard substances (4th class of hazard according to GOST 12.1.007-76). Study of the irritant action of Uritosom preparation was carried out in two series of experiments. In the first series of experiments was determined irritating action by conjunctival swab sampling method, in the second - by skin application. The study of the sensitizing action of the drug was determined by the method of maximum sensitizing effects. The authors have found that the preparation has no irritating and sensitizing effect on the tissue in its application zone. On this basis, Uritosom preparation at different ways of application is low-toxic and it can be recommended for clinical research
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USE OF FLUCONAZOLE FOR TREATMENT OF CHRONIC ENDOMETRITIS AT COWS
DescriptionThat article is of interest to practicing veterinarians. Currently, the biggest obstacle in the development of dairy farming is infertility at cows, which is caused by the presence of diseases of the reproductive organs, most of which is occupied by acute and chronic endometritis. The frequency of occurrence of chronic endometritis at cows reaches high levels, from 10 to 66.3%, averaging 14%. One of the direct causes of chronic endometritis is association of pathogenic and opportunistic microorganisms and fungi. Many chemotherapeutic agents which are designed for prophylaxis and treatment of acute postpartum endometritis do not give a high therapeutic effect in the treatment of chronic endometritis or amount and frequency of application drugs is very high. Analyzing the data, the authors developed a new drug which has fungicidal and antibacterial actions - Florinazol. The experiments showed that the use the Florinazol preparation in combination with myotropic, pathogenetic and vitamin preparations gives 90% of therapeutic efficiency, while the frequency of administration of the drug was on average 3 fold, and the duration of treatment was 5 days
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EXPERIENCE OF USING NATURAL MINERAL COMPOUNDS FOR METABOLIC DISORDERS IN CATTLE
DescriptionIn this study we show the results of the use of natural mineral compounds in metabolic disorders in cattle-breeding complexes of industrial type. According to official data for 2013-2015, based on the biochemical analysis of blood of cattle, that was held in some farms of Samara region, significant metabolic disorders were determined due to decrease in total protein level on 31,5% in average, decrease in alkali reserve – on 26,9% of samples, decrease in calcium concentration – on 40,7%, decrease of the phosphorus – on 8,1%, decrease in carotene – on 81,7% and glucose – on 84,3% of studies. Clinical examination of herd revealed a high level of animals with obvious signs of mineral metabolism disorders (osteodystrophy and rickets of alimentary origin) and comorbidity (nutritional anemia, gastroenteritis, pneumonia, disturbance of protein, carbohydrate and vitamin metabolism, and others). The use of complex natural compounds improves the efficiency of the traditional complex of treatment and prophylaxis, causing an increase in the total concentration of calcium in the blood serum on 10-55%, increase in calcium-phosphorus ratio till 1,27-2,3, increase in annual growth rate of young animals’ body weight on 8,2-44,8%, increase in milk production on 5,9-16,3%. Preparations have an antianemic action, normalize indicators of micronutrient metabolism of proteins and carbohydrates, enhance non-specific resistance factors and prevent the development of non-contagious internal pathology
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DISTRIBUTION AND SPECIES COMPOSITION OF PECTORIS AND RHODOCOCCUS
DescriptionThere are numerous reports about the possibility of sensitization to tuberculin animals when infected with pectoris and Rhodococcus and it is considered to be expedient to create one monoallergenov to differentiate allergic reactions. In this context, the spread of pectoris and Rhodococcus in nature, the general physico-chemical and biological properties of mycobacteria, increasingly emerging reports of a possible sensitization of the microorganism, require a detailed study of them in order to determine the specificity of allergy
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MONITORING OF THE CANICOLA FEVER IN POPULATION OF CATTLE AND WILD FAUNA OF THE AMUR REGION
DescriptionThe article presents results of researches of authors on prevalence of a canicola fever in populations of cattle and wild rodents in the Amur region. The research objective consisted in studying of etiological structure of a canicola fever of cattle and establishment of the dominating canicola fever originator serotypes at the rodents living in the Amur region. Results of researches showed that in etiological structure of a canicola fever of cattle in the Amur region the admixed serogroups and a serogroup of Sejroe dominate. The natural reservoir of a canicola fever in the Amur region are populations of gophers, chipmunks, muskrats and voles. The highest percent of the infected individuals is taped in population of gophers (57,1 %). Level of contamination of animals in populations of muskrats and chipmunks made 20 and 17,6 % respectively. Contamination the canicola fever originator in populations of voles was at the level of 8-9 %
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Description
The article presents results of the study on the use of associations of probiotic bacteria in black-and-white breed calves. We have analyzed the effect of associations of probiotic bacteria on hematological (red blood cells and white blood cells, hemoglobin and hematocrit) and blood biochemical parameters at calves. It was found that the associations of strains of Bifidobacterium bifidum DSM 20456, ATCC 29521, and Enterococcus faecalis H22; Bifidobacterium bifidum DSM 20456, ATCC 29521 and Enterococcus faecium UDC 86 do not have significant changes in the basic blood parameters of the animals, while improving some of counts during their use
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SEROLOGIC CONTROL OF SPECIFIC PROPHYLAXIS OF THE CANICOLA FEVER OF CATTLE
DescriptionResults of studying of the immune response of young growth of cattle to vaccination against a canicola fever are presented in article. Dependence of duration of circulation of antibodies in a blood of the vaccinated young growth of cattle from degree of intensity of an immune response on introduction of the vaccine is revealed. Studying of dynamics of antiserum capacities at cow calves of two-month age after immunization taped the weak immune response on introduction of a vaccine. It is expressed both in total absence of antibodies, or available antibodies in minute quantity to canicola fever of one of the serogroups which are a part of a vaccine. Use of immunomodulatory preparations for rising of efficiency of immunization of cow calves against a canicola fever is offered. It is established that application of "Ribotan" at vaccination of two-month calves against a canicola fever increases efficiency of immunization for 55,6 %
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BIOLOGICAL FUNCTIONS OF CAROTENOIDS AT CATTLE REPRODUCTION
DescriptionCarotenoid preparations are quite widely used in a health care, but in the veterinary and animal husbandry, their use is limited. In terms of livestock farms of the Krasnodar region and the Rostov region at the biochemical monitoring studies of the cattle blood the lack of carotene in the serum is revealed from 45 to 100 % of the samples. To study the biological function of carotenoid we used preparations, which are the oily solutions for injections: β-carotene (manufactured by FS 42-3867, which is produced from the biomass culture of the fungus Blakeslea trispora) and lycopene, emitted from plants. The cows in the test groups during the dry period and within two weeks after birth got carotenoid preparation subcutaneously at a dose of 10 ml per animal with an interval of 7 days. As a result, it was found out that the application of carotenoids has the most favorable conditions for the flow of labor and the postnatal period, which are manifested in the decrease in obstetric and gynecological diseases in cows and reduce the period of infertility. In the experimental groups the levels of vitamin A and carotene1,3 times higher (1,26 ± 0,14 μmol/L vs. 0,97 ± 0,09 μmol/L ) 1,8 times (0,34 ± 0 03 mg /% vs. 0.61 ± 0.11 mg /%) respectively in comparison with the parameters of the intact animals at a high level of confidence (P < 0,05). Phagocytic number and percentage of digestion of neutrophils increased by 8,5 %, the difference in the number of B-cells reached 9,1%, T-cells – 6,7%. In a humoral immunity found a significant increase in Ig A. After comparison of the level of lysozyme activity of blood serum was observed its reduction in all animals immediately after birth, but in the experimental groups this process was less pronounced. The use of carotene preparations helps to reduce the concentration of lipid peroxidation products in the body of cows (diene conjugates - by 16,6 %, ketodienes - by 35,7 %, malondialdehyde – by 11,3 %), which creates favorable conditions for the flow of the metabolic processes associated with ensuring the normal childbirth and post-partum involution of the genitals. In the group of cows, receiving the carotenoid lycopene, the dyspepsia morbidity of the newborn calves compared to a control decreased by 26,7 %, bronchopneumonia - by 13,3 %