№ 115(1), January, 2016
Public date: 27.01.2016
Archive of journal: Articles count 86, 182 kb
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22.00.00 Sociological sciences
22.00.00 Sociological sciences
DescriptionThe article is devoted to the analysis of deputy orders realisation as a part of the social programme devoted to the improvement of the citizens’ welfare. The regularity of the programme results’ indication is analysed as well as the municipal management efficiency assessment is given. Questions of social and economic efficiency are raised
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TRANSCRIPTOMIC ACTIVITY OF ESTROGEN-REGULATORY GENES IN MALIGNANCY UTERINE TISSUES
DescriptionUterine cancer is the sixth on prevalence of cancer among women in developed countries. Hyper-estrogen level by endogenous or exogenous origin plays the leading role in this disease pathogenesis. This study purpose was investigating the expression of genetic loci responsible for the estrogen reception and metabolism to better understanding of the molecular mechanisms of uterine tissues malignancy. We investigated the relative expression of genes (CYP1A 1, CYP1A 2, CYP1B 1, CYP19A, ESR1, ESR2, GPER, STS, SULT1A and SULT1E1) by real-time PCR in tumor and conditionally healthy uterine tissues of 27 female patients in Southern Russia aged 38-72 years with histologically confirmed diagnosis of uterine cancer. It is found that transcription activity of these genes during malignancy of uterine tissues depends of female patients age and the stage of tumor cells differentiation. It is found that malignancy change in the transcriptional activity of investigated genes in uterine tissue depends of patients age and stage of tumor cells differentiation. Particularly, it was found, that changes of gene transcription balance of enzymes that provide sulfation and hydrolysis of steroid sulfates is depending of patient age and the degree of tumor cells differentiation. In addition, the sinking of gene expression of nuclear estrogen receptor ESR1 as lowering cell differentiation of tumor tissues. We have also shown gene expression of nuclear estrogen receptor ESR1 decline as lowering cell differentiation of tumor tissues
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Description
Via the method of visualizing the excitation in the high frequency field there were discovered the efferent signals in the frog medulla oblongata, which were related to the heart rhythm
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Description
In the high frequency electric field we have revealed afferent signals in the frog medulla oblongata for learning the heart vago - sympathetic trunk rhythm
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Description
In this article we have listed the data concerning the influence of the respiration depth on the parameters of the cardiopulmonary synchronism depending on the personality type
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PREDICTION OF ADAPTATION OF PATIENTS TO FIXED TEETH USING REGULATORYADAPTIVE STATUS RATE
DescriptionUsing the of rate regulatory-adaptive status we can make a prediction for adaptation of patients to fixed teeth
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THE ASSESSMENT OF THREATENED MISCARRIAGE USING REGULATIONADAPTIVE STATUS
DescriptionThe index definition of regulatory-adaptive status in women with the threat of termination of pregnancy in the first trimester is a highly predictor of pregnancy outcome and should be used in obstetric hospitals and antenatal clinics
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Description
The aim of the research is to assess the effect of different kinds of non-drug correction of climacteric disorders on the sexual function in female patients with metabolic syndrome during the period of fading of the ovaries. The research includes 330 women aged 45-50 and having metabolic symptoms. Three groups were formed: the main group, the first control group, and the second control group. In the main group the non-drug treatment (diet therapy, psychotherapy, physical therapy, exercise therapy) and the vitaminmineral treatment were combined. In the first control group, only non-drug treatment was used. In the second control group, only the vitamin-mineral treatment was used. The marital status was determined. The female sexual function index (FSFI) was determined based on six parameters – desire, arousal, lubrication, orgasm, satisfaction, and pain – before the treatment and six months after the treatment. It was identified that sexual disorders are of complex character in the women of the studied group; very common is the loss of libido. The results show the highest effectiveness of the complex approach (nondrug treatment combined with the vitamin-mineral treatment) in the sexual dysfunction correction in female patients with metabolic syndrome in the climacteric period compared to the use of only the stated methods of non-drug treatment or only the vitamin-mineral treatment
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SELECTION OF FETAL CELLS CIRCULATING IN MATERNAL BLOOD FOR NONINVASIVE PRENATAL DIAGNOSIS
DescriptionTrophoblast cells circulating in maternal blood may serve as potential sources of genetic information for screening in obstetric practice approaches to noninvasive prenatal diagnosis. The material for the study was whole blood of pregnant women of gestational ages of 8-12 weeks in a volume of 10 ml. stabilized with heparin. Enrichment was performed by the method of gradient centrifugation and magnetic separation (CD45–) with fluorescent staining negative fractions labeled with antibodies to antigens of trophoblasts (HLA-G, and Trop-2) to conduct flow cytometry and sorting of cells on glass slides. Single cell candidates using laser micro dissection were transferred into a vial for subsequent whole-genome amplification, providing sufficient representativeness of their genome. Fetal origin of the genetic material was confirmed by comparison of alleles of the HLA genes of the parents and cells candidates. It is possible to improve significantly the accuracy and versatility of non-invasive prenatal diagnosis using comparative genomic hybridization using chips (аCGH)
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USING MECHANISMS OF FORMALIZATION OF DIDACTIC CONTENT FOR SKILLS DEVELOPMENT MONITORING
DescriptionThe relevance of an effective system of professional development for science-intensive and high-tech industries demonstrates not only the need to promptly respond to the global challenges of the modern economy, but also the presence of professionals able to reform the Russian economy in conditions of adverse effects of the sanctions. The leading role in these processes is assigned to highly qualified staff, which is formed in the process of training specialists within the system of continuous professional education and training (CPEandT). Expansion of the use of the system of CPEandT in modern educational technology (MET) opens new possibilities for advanced training and monitoring of this process by formalizing mechanisms of didactic content. We have developed specific mechanisms of formalization of the bestknown relationship between the information flow of didactic content and scope of knowledge of professional disciplines plan of professional development, as well as the possibility of their use for the monitoring of the process. The article discloses mechanisms of formalization of the process of professional development for science-intensive and high-tech industries, which will actively contribute to their successful implementation and monitoring