Kuban State Medical University
Author list of organization
List of articles written by the authors of the organization
-
PSEUDOEXFOLIATION SYNDROME AS A RISK FACTOR FOR CENTRAL RETINAL VEIN OCCLUSION
DescriptionThe retrospective study of patients with retinal vein occlusion and frequency of pseudoexfoliation syndrome is made in this study. Retinal vein occlusion is the second most common type of retinal vascular disorder, after diabetic retinal disease, and may develop with a consequent reduction in visual acuity. Pseudoexfoliation syndrome is an age-related disease characterized by the production and accumulation of a fibrillar extracellular material in several ocular tissues We have analyzed data of 73 patients with retinal vein occlusion. It was detected that risk of central vein occlusion is higher in patients with pseudoexfoliation syndrome (23,3% of patients were diagnosed as having pseudoexfoliation syndrome). In the branch retinal vein occlusion group only 9,3% of patients had pseudoexfoliation syndrome. In control group only 8,6% of patients had this syndrome. Control group was made of 80 patients similar in age without any retinal and cardiovascular abnormalities, patients with episodes of ocular hypertension, glaucoma, and those who had undergone cataract surgery were excluded from the study. Pseudoexfoliation syndrome may be considered as an independent risk factor for development of central retinal vein occlusion
-
SECONDARY IMMUNODEFICIENCIES OF SMALL PETS AND THEIR CORRECTION USING MURAMYLDIPEPTIDE
DescriptionThe revolutionary discoveries of recent years in immunology has proved that protection from infections and biological aggression leading role played by innate immunity, which leads to the launch and subsequent work of specific adaptive immunity. Today, it is well-known that almost any pathology of the animal affects the immune system and creates an immune imbalance, leading to development of chronic pathological process, frequent relapses and to the development of different kind of complications. Secondary immunodeficiency states are widely distributed and differ in many etiological factors age, nutritional, medicinal, infectious and neoplastic nature, which leads to increased susceptibility of animal to various раthogenic factors, the weakening of the body. Awareness of the role of immunological disorders in the pathogenesis of a number of diseases has led to the need use in veterinary medicines that are aimed to influence on the immune system of the animal at the known molecular mechanism, to combine safety with high clinical efficacy. In this respect, a promising immunomodulators of microbial origin, due to the knowledge of the recognition mechanisms of the innate immune system such as bacteria as a whole, separate structural units, including mini-optimal biologically active fragments. This review is dedicated to one of the immunomodulator of microbial origin – which is an analog of biologically active fragment of muramyldipeptide of bacterial cell walls ‒ glucosaminylmuramildipeptide (GMDP), which is the active substance of registrated in Russia drug with the trade name Glicopin for use in veterinary practice. The drug showed high efficiency when used in cats, dogs, rodents, ferrets with infections of bacterial and viral etiology; cancer; with the aim of improving the natural resistance of the organism of young and old animals; enhance the effectiveness of vaccination in immunocompromised animals; postvaccine reduce complications; reduce stress financial position, such as during transportation and various veterinary treatments; injuries and on-line intervention (for stimulation of repair processes and tissue regeneration); prevention of immunodeficiency in newborn animals; the reduction of postpartum involutional processes in the uterus. Analysis of literature data allows us to consider an important outcome of immunologiс discoveries of recent years is the change of views on the question of the treatment of infectious diseases and the role of drugs as activators of innate immunity, among which an important role is played by a synthetic analogue of muramyldipeptide (GMDP) is a drug with a known molecular mechanism of action
-
Description
One of the reasons extensions acute intestinal diseases in newborn calves and piglets is absence at them of formed immune system and colonization resistance. For this reason, their intestine often occupies relative pathogenic microorganisms, which in the subsequent cause diarrheal diseases. The characteristic feature of the last time is the fact that these diseases have the associated disposition and composition of association can be the most various but not only biological objects (for calves and piglets), and also territorial borders. The goal of this work was in comparative study of the structure microorganisms, which were isolated from newborn calves and piglets at acute intestinal diseases in Krasnodar territory and the establishment of the dominant species. During the bacteriologic examination of pathological material was detach and finger 1299 isolate calves and 476 from piglets which was found to belonged to 6 families: Enterobacteriaceae, Streptococcaceae, Enterococcaceae, Pseudomonadaceae, Alcaligenaceae, Alteromonadaceae. Studies have shown that dominant logic value in nosological profile of the allocated bacteria belongs to enterobacterium, enterococcus, streptococcus, the share of which in the general pool of isolates has made 70,1%, 15,9% and 11,1%, respectively. At the same time among the enterobacterium detached as from calves, and pigs, the prevailing species was E. coli (55,6%), streptococcus – S. bovis (24,9%), enterococcus – E. faecium and E. faecalis (88,3%). Meanwhile, along with the general character of frequency separation of certain types of bacteria, also their specific preference is set. That why from calves there were more often selected enterobacter, citrobacter, kluyvera, E. faecalis, S. cricetus, S. mitior, S. parauberis and P. aeruginosa. Whereas from pigs more often were allocated protei, providencia, shigella, E. mundtii, E. casseliflavus, S. acidominimus, S. oralis, S. pneumoniae, S. vestibularis и Alcaligenes fecalis than from pigs
-
Description
The research shows the possibility of extended preimplantation genetic screening (PGD) that allows to improve the strategy of selection of embryos that satisfies not only the requirement of the absence of chromosomal abnormalities, but also includes their additional check for predisposition to various diseases, as well as the choice of the embryo with the most optimal HLA haplotype in cases with expressed compatibility of parents for HLA-genes