14.00.00 Medical sciences
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MEDICAL ASPECTS OF TOXICAL DANGERS IN COMMERCIAL SHIPS (REVIEW)
DescriptionThe article presents an analysis of features of the organization of special medical and prophylactic support on commercial ships. First-aid treatment at poisoning of crews of the most widespread toxic matter (poisonous gases, oil products, methane, coolants, and fumigants) has been considered. It is noted that medical aspects of toxic dangers on the water transport have to include prevention of the pathological states of health of seamen, timely medical support of the ship, early diagnostics of pathological states, sorting of injured persons and the organization of first emergency medical aid
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PATHOLOGY OF CARDIOVASCULAR SYSTEM AT PERSONNEL OF COMMERCIAL FLEET
DescriptionIt is known that there are most widespread the diseases of cardiovascular system among the examined seamen. We have carried out the analysis of distribution of concrete nosological forms of pathology of cardiovascular system and concomitant diseases (gastrointestinal tract, nervous system, ENT organs, the musculoskeletal apparatus and others). Results of preventive screening of the crew personnel performed in 2007–2010 by medical commission of Novorossiysk clinical center of Russia’s Federal Medico-Biological Agency were subject to scientific research. 3352 seamen aged from 18 to 60 years (middle age 27,2+1,3 years), among which 2627 surveyed – personnel of bluewater shipping, 725 surveyed – personnel of domestic shipping have been subjected to studying. The examined contingent is ranged taking into account professional groups. It is revealed that cardiovascular pathology is almost equally widespread in all professional groups of personnel of ships of domestic and blue-water shipping. This pathology occurs at 13,5–21% of the seamen corresponding who had medical examination. The main group of the examined seamen (79–96,7%) belongs to the category «almost healthy» and suitable for work in the sea. Among revealed pathology at seamen, the high specific weight (63– 70%) belongs to diseases of cardiovascular system. Probable intensive work and harmful factors of the ship environment in each of professional groups exert significant negative impact on psychic and somatic health of seamen. Neurocirculator dystonia (hypertensive and cardio types) dominates in structure of cardiovascular pathology registered at seamen of both professional groups. The associated diseases (71–82%) meet more often at persons with hypertension, manifesting forms of atherosclerosis and ischemic disease. In both groups, we have noted the high percent of violations of digestive tract, musculoskeletal apparatus, alimentary and constitutional obesity and eyesight. However, alimentary and constitutional obesity and diseases of musculoskeletal apparatus are most characteristic of the personnel of ships performing long maritime traffic. Obviously, this phenomenon is connected with hypodynamia
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VISUALIZATION OF THE SPACE OF INITIAL EXCITATION AREA IN SINOATRIAL NODE OF THE CAT,S HEART
DescriptionThe article describes the visualization of the space of initial excitation area in sinoatrial node of the cat’s heart
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The article shows that via the dynamics of the regulatory adaptive status it is possible to asses the effectiveness of the treatment for the patients with angina pectoris (third functional class)
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The article analyzes the effectiveness of plasmapheresis and xenon therapy in 40 patients with gynecological cancer who underwent surgery in the amount of extended panhysterectomy about cervical cancer, who developed signs of post-castration syndrome in the immediate postoperative period. The content of gonadotropic pituitary hormones was determined in the blood of patients with cervical cancer and healthy women - follicule-stimulating, luteinizing hormones, prolactin; steroid hormones: estradiol, testosterone, cortisol; thyroid hormones. It is found that xenon therapy has a more pronounced antistress, hormone-modulating, sedative and antidepressant effect and is more preferable to treat post-castration syndrome. Performing of plasmapheresis in this aspect is most justified in patients with concomitant metabolic syndrome
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PROGNOSTIC SIGNIFICANCE OF LYMPHOCYTIC INFILTRATION IN VULVAR CANCER PATIENTS
DescriptionA retrospective immunohistochemical study of lymphocyte and macrophage infiltration in tumor tissue of 84 vulvar cancer patients with a long (over 2 years) and short (less than 2 years) remission was performed to determine a possible role of immunologic microenvironment of tumors in maintaining remission. Vulvar cancer patients with a short remission period were aged 46-85 years, mean age 67 years. 15.8% of them had stage I of the disease, 21% - stage II, 47.4% - stage III and 15.8% - stage IV. The average duration of remission in this group was 11 months. Patients with a long remission period were aged 27-71 years, mean age 48 years. 38.5% of them had stage I of the disease, 53.8% - stage II and 7.7% - stage III. The average duration of remission in this group was 8 years. Histological study showed squamous cell carcinoma in all patients. Stroma and parenchyma of tumor tissues demonstrated lymphocyte and macrophage infiltration of various degrees with the predominance of T-lymphocytes. CD8+ cells prevailed in tumor tissue of patients with a long remission period (over 2 years), while a higher level of CD4+ Т-lymphocytic infiltration was associated with a short remission (less than 2 years) and a poor prognosis. These differences allow prediction of the vulvar cancer course and its early or late recurrence
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VISUALIZATION OF NEURONAL ACTIVITY IN FROG’S VAGO-SYMPATHETIC TRUNK
DescriptionIt is proposed to use the visualization method of propagation of excitation in the nerve in a highfrequency electric field
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While studying the content of hypoxia-inducible factor 1-alpha and vascular endothelial growth factor in the tumor tissue, oral fluid and peripheral blood of 141 patients with oral mucosa cancer T1-3N0-2M0, it was shown that the development of purulent inflammatory postoperative complications in patients with oral mucosa cancer is associated with an increased expression of HIF-1α in the tissue and its translocation from the cytoplasm to the nucleus, activation of the neoangiogenesis processes. It is informative to determine HIF-1α factor in the blood serum, which, for further development, can be used as a non-invasive diagnostic marker to predict the postoperative course in this category of patients
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CLINICAL AND MORPHOLOGICAL FACTORS AND PREDICTION PARAMETERS OF CELL CYCLE IN ESOPHAGEAL CANCER
DescriptionThe aim of the study is to compare the traditional clinicopathologic factors and prognosis of cell cycle parameters, such as ploidy, cell cycle kinetics, as well as the study of DNA content in the tumor tissue of patients with esophageal cancer. Cancer of the esophagus - a very aggressive malignant disease, most commonly manifested impaired swallowing. As a rule, this type of cancer pathology is characterized by unfavorable outcome. Ploidy and cell proliferation activity, defined by the content of the DNA of the tumor - synthesizing cells are one of the important indicators of the growth rate of malignancy and prognosis. The study was performed on tumor tissue fragments of the 30 patients operated on for cancer of the esophagus. DNA study - conducted in the open cell material aftercare. DNA cell content was determined by flow cytometry BD FACSCanto II. By studying the DNA-cytometric parameters, we found the prevalence of aneuploid tumors in 66.7%. It was shown that DNAcytometric parameters are independent of gender. Major weight of diploid and aneuploid cell tumors of the esophagus was in G0 / 1 phase of the cell cycle. Comparative analysis of DNA - cytometric parameters and the degree of differentiation of esophageal tumor revealed a prevalence of aneuploid tumors in all the test cases. content distribution pattern of tumor cells was found in the G0 / G1-, G2 + M -, S - phase of the cell cycle at different stages of the disease
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The aim of the research is to assess the effect of different kinds of non-drug correction of climacteric disorders on the sexual function in female patients with metabolic syndrome during the period of fading of the ovaries. The research includes 330 women aged 45-50 and having metabolic symptoms. Three groups were formed: the main group, the first control group, and the second control group. In the main group the non-drug treatment (diet therapy, psychotherapy, physical therapy, exercise therapy) and the vitaminmineral treatment were combined. In the first control group, only non-drug treatment was used. In the second control group, only the vitamin-mineral treatment was used. The marital status was determined. The female sexual function index (FSFI) was determined based on six parameters – desire, arousal, lubrication, orgasm, satisfaction, and pain – before the treatment and six months after the treatment. It was identified that sexual disorders are of complex character in the women of the studied group; very common is the loss of libido. The results show the highest effectiveness of the complex approach (nondrug treatment combined with the vitamin-mineral treatment) in the sexual dysfunction correction in female patients with metabolic syndrome in the climacteric period compared to the use of only the stated methods of non-drug treatment or only the vitamin-mineral treatment