16.00.00 Veterinary sciences
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Description
The influence of new tissue preparation on immunobiochemistric blood indicators of cows and their calves has been evaluated
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Description
Mixed infestations have been reported in cattle with EI - 73.5%. The mixed infestations of cattle productive performance of animals decreased proportional to the intensity of infestation E.granulosus and D. lanceatum. In the carcasses of calves, depending on the AI of worms, we have marked the reduction in the yield of muscle tissue from 72.8 to 63.2%, fat - from 9.2 to 3.0% (3 times). Heavily infested bodies have shown a shortfall of 60.1 kg of meat in slaughter weight
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SECONDARY IMMUNODEFICIENCIES OF SMALL PETS AND THEIR CORRECTION USING MURAMYLDIPEPTIDE
DescriptionThe revolutionary discoveries of recent years in immunology has proved that protection from infections and biological aggression leading role played by innate immunity, which leads to the launch and subsequent work of specific adaptive immunity. Today, it is well-known that almost any pathology of the animal affects the immune system and creates an immune imbalance, leading to development of chronic pathological process, frequent relapses and to the development of different kind of complications. Secondary immunodeficiency states are widely distributed and differ in many etiological factors age, nutritional, medicinal, infectious and neoplastic nature, which leads to increased susceptibility of animal to various раthogenic factors, the weakening of the body. Awareness of the role of immunological disorders in the pathogenesis of a number of diseases has led to the need use in veterinary medicines that are aimed to influence on the immune system of the animal at the known molecular mechanism, to combine safety with high clinical efficacy. In this respect, a promising immunomodulators of microbial origin, due to the knowledge of the recognition mechanisms of the innate immune system such as bacteria as a whole, separate structural units, including mini-optimal biologically active fragments. This review is dedicated to one of the immunomodulator of microbial origin – which is an analog of biologically active fragment of muramyldipeptide of bacterial cell walls ‒ glucosaminylmuramildipeptide (GMDP), which is the active substance of registrated in Russia drug with the trade name Glicopin for use in veterinary practice. The drug showed high efficiency when used in cats, dogs, rodents, ferrets with infections of bacterial and viral etiology; cancer; with the aim of improving the natural resistance of the organism of young and old animals; enhance the effectiveness of vaccination in immunocompromised animals; postvaccine reduce complications; reduce stress financial position, such as during transportation and various veterinary treatments; injuries and on-line intervention (for stimulation of repair processes and tissue regeneration); prevention of immunodeficiency in newborn animals; the reduction of postpartum involutional processes in the uterus. Analysis of literature data allows us to consider an important outcome of immunologiс discoveries of recent years is the change of views on the question of the treatment of infectious diseases and the role of drugs as activators of innate immunity, among which an important role is played by a synthetic analogue of muramyldipeptide (GMDP) is a drug with a known molecular mechanism of action
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GLYOXAL - DISINFECTANT OF WIDE RANGE OF ANTIMICROBIAL ACTION
DescriptionThe article gives brief information about the development of the domestic technology of industrial synthesis of glyoxal and presents the results of the bactericidal properties of it on various micro-organisms and depending on the structure of the treated surface
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DYNAMICS OF ANTIBODY FORMATION AT ANIMALS IN RESPONSE ON ANATOXIN INTRODUCTION
DescriptionExperience on studying of immune genetic properties of esherechious anatoxin is described in the article. There was revealed that new complex of inactivated toxins of intestinal rod is able to stimulate antibodies forming in animal organisms.
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DYNAMIC CHANGES OF ANTIBIOTIC SENSITIVE AGENTS OF DISEASES OF СALFS
DescriptionStudy of dynamic sensitive of microorganisms shows wave shape change of characters with change of dominance with sensitive aminoglicozids and hinolone ftorhinolone groups of drugs
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Description
In this study, the authors have defined the acute, subchronic and chronic toxicity of Uritosom preparation, and also its skin-irritating and sensitizing action. The studies that determined the acute toxicity of the drug Uritosom found that remedy which intended for the treatment and prevention of diseases of the genitourinary system with internal method of appointment during the entire observation period did not cause the death and acute toxicity in laboratory animals. In the study of subchronic and chronic toxicity of the drug Uritosom throughout the observation period in both experimental groups death and acute intoxication in animals not registered, also there were no negative phenomena in behavior, reflexes were saved. Consequently, the preparation according to the degree of impact on the body of warm-blooded animals refers to low-hazard substances (4th class of hazard according to GOST 12.1.007-76). Study of the irritant action of Uritosom preparation was carried out in two series of experiments. In the first series of experiments was determined irritating action by conjunctival swab sampling method, in the second - by skin application. The study of the sensitizing action of the drug was determined by the method of maximum sensitizing effects. The authors have found that the preparation has no irritating and sensitizing effect on the tissue in its application zone. On this basis, Uritosom preparation at different ways of application is low-toxic and it can be recommended for clinical research
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VALUE OF BIOLOGICALLY ACTIVE POINTS AT THE PATHOLOGY OF DOGS’ LIVER
DescriptionDependence between parameters of blood at healthy and sick dogs is established at sharp and chronic hepatic insufficiency with biological potential BAP, responsible for a functional condition of a liver. BAP can be a trouble-shooting test of functional activity of a liver
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Description
The article presents some results on evaluation of an experimental viral vaccine against goat pox for its efficacy in the disease-affected areas of the Republic of Tajikistan. The epizootological data on small ruminant pox in the Republic within the last 50 years are analysed. The viral vaccine against goat pox may be used for goat pox prophylaxis in Tajikistan