16.00.00 Veterinary sciences
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BIOLOGICAL FUNCTIONS OF CAROTENOIDS AT CATTLE REPRODUCTION
DescriptionCarotenoid preparations are quite widely used in a health care, but in the veterinary and animal husbandry, their use is limited. In terms of livestock farms of the Krasnodar region and the Rostov region at the biochemical monitoring studies of the cattle blood the lack of carotene in the serum is revealed from 45 to 100 % of the samples. To study the biological function of carotenoid we used preparations, which are the oily solutions for injections: β-carotene (manufactured by FS 42-3867, which is produced from the biomass culture of the fungus Blakeslea trispora) and lycopene, emitted from plants. The cows in the test groups during the dry period and within two weeks after birth got carotenoid preparation subcutaneously at a dose of 10 ml per animal with an interval of 7 days. As a result, it was found out that the application of carotenoids has the most favorable conditions for the flow of labor and the postnatal period, which are manifested in the decrease in obstetric and gynecological diseases in cows and reduce the period of infertility. In the experimental groups the levels of vitamin A and carotene1,3 times higher (1,26 ± 0,14 μmol/L vs. 0,97 ± 0,09 μmol/L ) 1,8 times (0,34 ± 0 03 mg /% vs. 0.61 ± 0.11 mg /%) respectively in comparison with the parameters of the intact animals at a high level of confidence (P < 0,05). Phagocytic number and percentage of digestion of neutrophils increased by 8,5 %, the difference in the number of B-cells reached 9,1%, T-cells – 6,7%. In a humoral immunity found a significant increase in Ig A. After comparison of the level of lysozyme activity of blood serum was observed its reduction in all animals immediately after birth, but in the experimental groups this process was less pronounced. The use of carotene preparations helps to reduce the concentration of lipid peroxidation products in the body of cows (diene conjugates - by 16,6 %, ketodienes - by 35,7 %, malondialdehyde – by 11,3 %), which creates favorable conditions for the flow of the metabolic processes associated with ensuring the normal childbirth and post-partum involution of the genitals. In the group of cows, receiving the carotenoid lycopene, the dyspepsia morbidity of the newborn calves compared to a control decreased by 26,7 %, bronchopneumonia - by 13,3 %
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PHARMACODYNAMIC EFFECTS OF APPLICATION OF POLISILAR PREPARATION IN PIG PRODUCTION
DescriptionAn accelerated growth of farm animals in order to obtain maximum productivity is possible due to introduction stimulating additives and preparations based on them into the rations. One of such tools is Polisilar - complex preparation, which includes components that have a positive impact on various aspects of the animal metabolism in the conditions of physiological disorders. At the same time components of the preparation due to its high bioavailability exhibit a potentiating effect in the body that allows getting a more pronounced effect on its use. Studies were conducted on pigs 3-3.5 months age and showed that the Polisilar preparation has a positive effect on the clinical and physiological status of the animals and exhibits a pronounced growth stimulating effect, increasing the weight gain of pigs by 14.3%. In addition use of the preparation in rations of growing pigs has a normalizing effect on red blood and blood forming organs, increasing the number of red blood cells by 18.7%, hemoglobin - by 24.5%. Polisilar stimulates protein, carbohydrate and mineral exchanges, stabilizes the functional activity of the liver, reducing the toxic load on hepatocytes. Therefore, the preparation Polisilar has a pronounced biological and pharmacological activity and can be used in animal husbandry as an effective stimulant
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Description
In this study, the authors have defined the acute, subchronic and chronic toxicity of Uritosom preparation, and also its skin-irritating and sensitizing action. The studies that determined the acute toxicity of the drug Uritosom found that remedy which intended for the treatment and prevention of diseases of the genitourinary system with internal method of appointment during the entire observation period did not cause the death and acute toxicity in laboratory animals. In the study of subchronic and chronic toxicity of the drug Uritosom throughout the observation period in both experimental groups death and acute intoxication in animals not registered, also there were no negative phenomena in behavior, reflexes were saved. Consequently, the preparation according to the degree of impact on the body of warm-blooded animals refers to low-hazard substances (4th class of hazard according to GOST 12.1.007-76). Study of the irritant action of Uritosom preparation was carried out in two series of experiments. In the first series of experiments was determined irritating action by conjunctival swab sampling method, in the second - by skin application. The study of the sensitizing action of the drug was determined by the method of maximum sensitizing effects. The authors have found that the preparation has no irritating and sensitizing effect on the tissue in its application zone. On this basis, Uritosom preparation at different ways of application is low-toxic and it can be recommended for clinical research
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THE EFFECT OF DALARGIN ON MYELOID LINK OF WHITE RATS' BLOOD SYSTEM WITH EXPERIMENTAL HYPOTHYROIDISM
DescriptionUnder conditions of white rats' hypothyroidism the changes were studied in myeloid link of blood system and corrective action of dalargin. It has been stated that dalargin causes lasting leukopenia, short-time eosinopenia with consequent normalization of their number and momentarily stimulates neutrophilopoiesis
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Description
This article presents the results of testing the effectiveness of electrochemically-activated solutions of sodium chloride for disinfection of the facilities contaminated with highly pathogenic avian influenza
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TREATMENT OF CHRONIC ENDOMETRITIS WITH THE NEW DRUG FLORINAZOL
DescriptionIn the article data on spread of chronic endometritises at cows are provided. The microflora range, being in genitals of patients with a chronic endometritis of cows is determined. We have developed a new drug called Florinazol and we also determined his antimicrobic and fungicide activity. Researches on determination of acute and chronic toxicity, and also irritant action on a mucous membrane of a uterus and a vagina are conducted. Researches on studying of influence of Florinazol on blood biochemistry at rabbits are conducted. The optimum therapeutic dose and frequency rate of its introduction is determined. By results of researches it is established that 24,8% of the cows containing on a farm with loose housing content and 10,6% of cows on a farm with fastened content have a chronic endometritis. At the same time in uterus content in 84,3% of cases isolated associations of bacteria and mushrooms in 65,2%, in 34,8% - monocultures of microorganisms. Offered by us means the danger class belongs to substances lowdangerous by the 4th. Doesn't possess irritant action, doesn't exert a negative impact on blood biochemistry, and also has outstanding therapeutic performance of 90% in case of its application in a dose of 100 ml intra-vaginal at an interval of 48 hours
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Description
The opportunity of carrying out the accelerated indication of microbe contaminations of food products, food raw material and forages for animals with application of "VIDAS" immunological multiple parameter analyzer is investigated
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SEROLOGIC CONTROL OF SPECIFIC PROPHYLAXIS OF THE CANICOLA FEVER OF CATTLE
DescriptionResults of studying of the immune response of young growth of cattle to vaccination against a canicola fever are presented in article. Dependence of duration of circulation of antibodies in a blood of the vaccinated young growth of cattle from degree of intensity of an immune response on introduction of the vaccine is revealed. Studying of dynamics of antiserum capacities at cow calves of two-month age after immunization taped the weak immune response on introduction of a vaccine. It is expressed both in total absence of antibodies, or available antibodies in minute quantity to canicola fever of one of the serogroups which are a part of a vaccine. Use of immunomodulatory preparations for rising of efficiency of immunization of cow calves against a canicola fever is offered. It is established that application of "Ribotan" at vaccination of two-month calves against a canicola fever increases efficiency of immunization for 55,6 %
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Description
One of the reasons extensions acute intestinal diseases in newborn calves and piglets is absence at them of formed immune system and colonization resistance. For this reason, their intestine often occupies relative pathogenic microorganisms, which in the subsequent cause diarrheal diseases. The characteristic feature of the last time is the fact that these diseases have the associated disposition and composition of association can be the most various but not only biological objects (for calves and piglets), and also territorial borders. The goal of this work was in comparative study of the structure microorganisms, which were isolated from newborn calves and piglets at acute intestinal diseases in Krasnodar territory and the establishment of the dominant species. During the bacteriologic examination of pathological material was detach and finger 1299 isolate calves and 476 from piglets which was found to belonged to 6 families: Enterobacteriaceae, Streptococcaceae, Enterococcaceae, Pseudomonadaceae, Alcaligenaceae, Alteromonadaceae. Studies have shown that dominant logic value in nosological profile of the allocated bacteria belongs to enterobacterium, enterococcus, streptococcus, the share of which in the general pool of isolates has made 70,1%, 15,9% and 11,1%, respectively. At the same time among the enterobacterium detached as from calves, and pigs, the prevailing species was E. coli (55,6%), streptococcus – S. bovis (24,9%), enterococcus – E. faecium and E. faecalis (88,3%). Meanwhile, along with the general character of frequency separation of certain types of bacteria, also their specific preference is set. That why from calves there were more often selected enterobacter, citrobacter, kluyvera, E. faecalis, S. cricetus, S. mitior, S. parauberis and P. aeruginosa. Whereas from pigs more often were allocated protei, providencia, shigella, E. mundtii, E. casseliflavus, S. acidominimus, S. oralis, S. pneumoniae, S. vestibularis и Alcaligenes fecalis than from pigs
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THE FACTORS PROMOTING DISTRIBUTION AND UROLITIAZ'S DEVELOPMENT IN CATS
DescriptionThe authors were conducting researches on 36 unhealthy cats in a veterinary clinic in Orenburg, from 2014 till 2016, and they were diagnosed the urolithiasis. By the results of the researches, the influence of a season of year, age and breed on distribution and development of an urolithiasis disease in cats has been studied. At the same time, it is established that the urolithiasis disease usually occurs at cats from 2 up to 6 years, which makes 45,0% of all the studied animals. A disease outbreak at cats was observed during summer and autumn periods, generally, not purebred animals - 75% are subject to the disease, the rest 25% is such breeds as the British, Persian, Bengalese, Scottish; in addition, the influence of an unbalanced diet, non-compliance with the norms and the mode of feeding is noted