16.00.00 Veterinary sciences
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DETERMINATION OF ACUTE TOXICITY OF ROKSATSIN
DescriptionIn this article, the authors have defined the acute toxicity of Roksatsin preparation, which represents a 20 % aqueous solution of polyhexamethylene guanidinehydrochloride (PHMG). The acute toxicity of Roksatsin in the first series of experiments was studied on white mice upon intragastric administration. In the second series of the experiments, Roksatsin was administered subcutaneously to white rats and in the third series of experiments the preparation was administered intracisternally to cows. The results of the first series of experiments showed that Roksatsin by the internal method of appointment is slightly toxic to white mice. In this experiment not been a single case of acute intoxication and death of animals. Experiments to determine the acute toxicity of the preparation for white rats were performed in triplicate. In the first series of experiment, the LD50 was 4.8 ml/kg. It is found, that the calculated coefficients LD50 for other two series were close to the first one: the second - 4.2 ml/kg and the third - 4.5 ml/kg. Therefore, the authors found that the Roksatsin preparation upon subcutaneously administration according GOST 12.1.007-76 is a low-toxic compound (4th class of danger). As a result of the third series of the experiments, it was found that the intracisternally administration of Roksatsin preparation to cows in a dose of 5 ml is not toxic to the animal organism. Intracisternal administration of Roksatsin does not have a significant impact on the morphological and biochemical indices of blood. On this basis, Roksatsin preparation with different routes of administration is low-toxic and it can be recommended for clinical researches
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SOME IMMUNOBIOLOGICAL FEATURES OF RIFT VALLEY FEVER VIRUS OF ATTENUATED STRAIN
DescriptionThe article represents some results of Rift Valley virus culture characteristics, development of conditions for virus inactivation with teotropin, formalin or ethyleneimine dimer. A range of inactivants and optimal inactivation conditions, which provide the production of inactivated raw virus with preserved antigenic and immunogenic activity rates, is selected
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MORPHO-FUNCTIONAL STATE OF BROILER CHICKENS ADRENAL CAPSULES UNDER DIFFERENT METHODS OF MANAGEMENT
DescriptionAn impact analysis of abiotic factors of ecosystems on the metabolic processes of the broiler chicken organism under various methods of poultry operation has been carried out. The analysis results confirm that the enorganic biochemical processes are under the influence of the environment, and any changes in its condition cause the development of response reactions of the organism at the biochemical level. The source of control of the relative constancy of the milieu interieur is the interaction of tropic and effector hormones. Adrenocorticotropic hormone and cortisol are the main hormones of adaptation. The activity of the adrenal capsules turns to be an effector peripheral link of the reflex chain of the adaptive reaction of the organism. Adrenal hormones have a direct impact on tissue metabolism. The following aspects have been taken into consideration: technological growing conditions, production parameters, morphological blood values of chickens of different ages, quantitative content of adrenocorticotropic hormone and corticoid in the blood, morphology of the adrenal capsules. The abiotic factors of the cage management system contribute to an increase in the concentration of corticoid in the blood of broiler chickens, compared with this value of the broilers grown under the floor management
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Description
The level of development of modern medical equipment for the past 20-30 years is in constant development, many of the technologies and methods of treatment of certain diseases that were previously only available for the treatment of a person with success began to penetrate in the veterinary practice. The objective aim at the initial stage was the establishment of testing and suitability for the cultivation of autologous dermal fibroblasts animals of previously known techniques and the modernization of the existing techniques. Next, we had to carry out measurements of morphometric parameters and to identify structural features and functional activity of fibroblasts of different kinds of agricultural animals. Conclusions: The study showed the conducted morphometric autologous dermal fibroblasts tests allowed us to obtain the correlation line. In addition, to identify common patterns in the development and growth of fibroblasts derived from different species of agricultural animals. And also, to obtain material for comparative evaluation of the quality of the obtained cell cultures using entropy equivalent
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MONITORING OF THE CANICOLA FEVER IN POPULATION OF CATTLE AND WILD FAUNA OF THE AMUR REGION
DescriptionThe article presents results of researches of authors on prevalence of a canicola fever in populations of cattle and wild rodents in the Amur region. The research objective consisted in studying of etiological structure of a canicola fever of cattle and establishment of the dominating canicola fever originator serotypes at the rodents living in the Amur region. Results of researches showed that in etiological structure of a canicola fever of cattle in the Amur region the admixed serogroups and a serogroup of Sejroe dominate. The natural reservoir of a canicola fever in the Amur region are populations of gophers, chipmunks, muskrats and voles. The highest percent of the infected individuals is taped in population of gophers (57,1 %). Level of contamination of animals in populations of muskrats and chipmunks made 20 and 17,6 % respectively. Contamination the canicola fever originator in populations of voles was at the level of 8-9 %
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Description
The article contains a synthesis of modern views on the problem of ketosis and related metabolic disorders. We have given evidences of the exceptional role of hypoglycemia in the development of progressive metabolic diseases of cows during the transition period. The necessity of implementing a program for critical period with mandatory control of glycemia was substantiated
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METHODS AND MEANS OF TREATMENT OF THE PATHOLOGY OF DOGS’ LIVER
DescriptionEfficiency of correction of hepatic insufficiency at dogs by means of a complex method with application of reflexotherapy and a preparation based on silver is shown. After application of complex therapy for the ill dogs with SHI restoration of the clinical status for 6 days, and at with CHI for 8 days was marked. Biochemical indicators of blood with SHI reached level of healthy dogs for 14 days, and with CHI for 17 days
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Description
The article presents positive results of application of integrated ways (methods) of induction and synchronization of the sexual cycle in cows for wide practical application in accelerated (extended) reproduction of the herd cattle
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Description
Efficiency of correction of hepatic insufficiency of dogs with the help of a medicinal solution on a basis of cluster silver and bile is shown. After application of therapy for fallen ill dogs it was marked: restoration of the clinical status, disappearance of morbidity in the field of a stomach and yellownesses of mucous membranes for 7 day. After 16 days, biochemical parameters of blood achieved a level of healthy dogs
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TREATMENT OF CHRONIC ENDOMETRITIS WITH THE NEW DRUG FLORINAZOL
DescriptionIn the article data on spread of chronic endometritises at cows are provided. The microflora range, being in genitals of patients with a chronic endometritis of cows is determined. We have developed a new drug called Florinazol and we also determined his antimicrobic and fungicide activity. Researches on determination of acute and chronic toxicity, and also irritant action on a mucous membrane of a uterus and a vagina are conducted. Researches on studying of influence of Florinazol on blood biochemistry at rabbits are conducted. The optimum therapeutic dose and frequency rate of its introduction is determined. By results of researches it is established that 24,8% of the cows containing on a farm with loose housing content and 10,6% of cows on a farm with fastened content have a chronic endometritis. At the same time in uterus content in 84,3% of cases isolated associations of bacteria and mushrooms in 65,2%, in 34,8% - monocultures of microorganisms. Offered by us means the danger class belongs to substances lowdangerous by the 4th. Doesn't possess irritant action, doesn't exert a negative impact on blood biochemistry, and also has outstanding therapeutic performance of 90% in case of its application in a dose of 100 ml intra-vaginal at an interval of 48 hours