16.00.00 Veterinary sciences
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CLINICAL PHARMACOLOGY OF A NEW COMPLEX HEPATOPROTECTIVE PREPARATION
DescriptionThis article presents the results of the studies of the influence of a new complex hepatoprotective preparation on the basic system of the body, the mechanism of occurrence and manifestation of its biological effects, the dependence of this action from the components that are parts of the preparation, the dose, as well as the regularity of manifestation of possible side effects. The effect of the different doses of the preparation (1% and 2%) on the average daily weight gain and morphological and biochemical indices of the birds’ blood was studied. The conducted research determined a stimulatory influence of the preparation on the growth, development and safety of broiler chickens. The new hepatoprotector exhibits the properties aimed on revitalizing the erythro- and hematopoiesis and magnification of the cellular immunity against the exogenous influence. The use of the preparation helps to improve liver function and reduce the toxic load on hepatocytes, which manifests an increase in a number of metabolic parameters, such as total protein, glucose, calcium, phosphorus. We have noted an expressed hepatoprotective effect on the enzyme activity of AST and the remission of the cytolytic syndrome of the experimental chickens. Thereby it was found out that the complex hepatoprotective preparation has a pronounced pharmacological activity, providing a significant impact on the energy of the broiler chickens’ growth and their safety, morphological and biochemical indices of the blood and metabolic processes in the body of the bird
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USING OF SODIUM HYPOCHLORITE FOR TREATMENT OF SMALL PETS
DescriptionIn the present work we show the results of treatment of surgical diseases of the small domestic animals sodium hypochlorite. Sodium hypochlorite is an antimicrobial, anti-inflammatory and detoxifying agent. We used it in a topical treatment for dogs and cats with allergic, infected wounds and in the post operative period. A solution of sodium hypochlorite is produced by activation of 0.9% sodium chloride solution by electrochemical method using electrometers and "Key", produced by the NGO Pyrolyzer in St. Petersburg. The resulting solution is a colorless transparent liquid, one liter contains 600 mg of the active substance is sodium hypochlorite. In the treatment of surgical diseases in medicine apply modern systemic therapies (drug therapy - physiotherapy - operation-pharmacotherapy), uses the latest drugs targeted actions (antibiotics, immunomodulators, probiotics, enzymes and hormones). There are other methods, including alternative medicine. It is known that increased therapeutic effect on wound process leads to the reduction of the inflammatory response, which can sometimes block local regeneration processes; for dogs and cats moderate inflammatory response in the wound is a necessary condition for successful healing. A certain degree of inflammation of the wound is starting mechanism of reparative processes. These features were considered during the experiment and the selection of treatment regimens
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INDUCTION AND SYNCHRONIZATION OF REPRODUCTIVE FUNCTION OF DAIRY COWS IN INDUSTRIAL COMPLEXES
DescriptionBased on analysis of the etiopathogenesis of ovarian follicular cysts in cows and heifers we have developed a comprehensive method of treatment and prevention of them. Potassium iodide normalizes metabolism and has specific effects on the genitals, thyroid and pituitary glands, restores their function. Chlormadinone inhibits the secretion of pituitary gonadotropins depending on the dose of the drug, and estrofan promotes growth of ovarian follicles and the manifestation of hunting and estrus in cows
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IMMUNE BIOLOGICAL INDEXES OF DIFFERENT CATTLE PHYSIOLOGICAL GROUPS
DescriptionResults of research of immune biological indexes of different cattle physiological groups on the base of experimental farm “Lenin’s way” of Novokubanskiy region are considered in this article.
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Description
Immune biological indexes of cows, infected with cattle leukemia virus and fallen sick with leukemia in comparison with intact ones are considered in this article.
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Description
The article presents some results on evaluation of an experimental viral vaccine against goat pox for its efficacy in the disease-affected areas of the Republic of Tajikistan. The epizootological data on small ruminant pox in the Republic within the last 50 years are analysed. The viral vaccine against goat pox may be used for goat pox prophylaxis in Tajikistan
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VALUE OF BIOLOGICALLY ACTIVE POINTS AT THE PATHOLOGY OF DOGS’ LIVER
DescriptionDependence between parameters of blood at healthy and sick dogs is established at sharp and chronic hepatic insufficiency with biological potential BAP, responsible for a functional condition of a liver. BAP can be a trouble-shooting test of functional activity of a liver
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Description
In this study, the authors have defined the acute, subchronic and chronic toxicity of Uritosom preparation, and also its skin-irritating and sensitizing action. The studies that determined the acute toxicity of the drug Uritosom found that remedy which intended for the treatment and prevention of diseases of the genitourinary system with internal method of appointment during the entire observation period did not cause the death and acute toxicity in laboratory animals. In the study of subchronic and chronic toxicity of the drug Uritosom throughout the observation period in both experimental groups death and acute intoxication in animals not registered, also there were no negative phenomena in behavior, reflexes were saved. Consequently, the preparation according to the degree of impact on the body of warm-blooded animals refers to low-hazard substances (4th class of hazard according to GOST 12.1.007-76). Study of the irritant action of Uritosom preparation was carried out in two series of experiments. In the first series of experiments was determined irritating action by conjunctival swab sampling method, in the second - by skin application. The study of the sensitizing action of the drug was determined by the method of maximum sensitizing effects. The authors have found that the preparation has no irritating and sensitizing effect on the tissue in its application zone. On this basis, Uritosom preparation at different ways of application is low-toxic and it can be recommended for clinical research
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DYNAMIC CHANGES OF ANTIBIOTIC SENSITIVE AGENTS OF DISEASES OF СALFS
DescriptionStudy of dynamic sensitive of microorganisms shows wave shape change of characters with change of dominance with sensitive aminoglicozids and hinolone ftorhinolone groups of drugs
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DYNAMICS OF ANTIBODY FORMATION AT ANIMALS IN RESPONSE ON ANATOXIN INTRODUCTION
DescriptionExperience on studying of immune genetic properties of esherechious anatoxin is described in the article. There was revealed that new complex of inactivated toxins of intestinal rod is able to stimulate antibodies forming in animal organisms.