South Federal University
Author list of organization
List of articles written by the authors of the organization
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THE ROLE OF GAP JUNCTIONS IN THE DEVELOPMENT OF ASTROCYTIC HUMAN BRAIN TUMOR
DescriptionRecently, much attention is paid to research the role of cell-cell interactions by gap junctions in the process of malignant transformation and mechanisms of antitumor resistance. Meanwhile, the greatest interest is astrocytic tumors. Depending on the degree of malignancy, astrocytomas are divided into: pilocytic astrocytoma (Grade I), subependymal giant cell astrocytoma (Grade I), pleomorphic xanthoastrocytoma (Grade II), diffuse astrocytoma (Grade II), anaplastic astrocytoma (Grade III), glioblastoma (Grade IV ) gliomatosis cerebri (Grade IV). Information of literature devoted to astrocytic tumors (gliomas) - the most common brain tumor in large part obtained in studies in cell cultures and different contradictions. Along with data on the reduction of glial tumors cells communicability through GJ, there is evidence of an opposite character - a functionally active GJ in gliomas and inhibition of tumor growth by reducing intercellular communicability by GJ. However, up to now there have been no studies of the effect and function of hemichannels in cancer cells, which would provide detailed information on: 1) the characteristic of presence and relative abundance of hemichannels in cancer cells; 2) evaluation of absorption / release of hemichannels mediated molecules in tumor cells than in non-tumor cells; 3) functional consequences of activation and blocking of hemichannels in tumor cells and 4) the prognostic value of the expression / activation of hemichannels in human malignancies
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Description
The problem of environmental contamination by heavy metals is significant problem of urbanization. The search of ways of indication heavy metals pollution becomes actual, because of their simplicity and affordability. A widely used test objects for heavy metals pollution indicators are leafy mosses used for bioindication, because they are highly sensitive to any stress factor. The research shows that bioindication with using leafy mosses as test objects is highly effective method definition of heavy metals pollution. Using of bioindication methods are promising techniques for the assessment of the contamination of ecosystems by heavy metals. Through the use of this method, it is possible indication of pollution of the surface layer of air with heavy metals. The epiphytic moss (Pylaisia polyantha) growing in different zones of the city of Rostov-on-Don, was used for the heavy metals pollution biomonitoring of urbosystems. The accumulation features of heavy metals in the epitaphic pylaisiella moss (Pylaisia polyantha) in the territory of the city of Rostov-on-Don have been considered. pylaisiella moss (P. polyantha) accumulates the largest amounts of the following heavy metals: Zn, Cr, Pb, Sr, Ni (Kc to 1.07), and Cu. According to the Kc values, all the studied elements accumulated by pylaisiella moss form the following series of biological uptake: Zn > Pb > Sr > Cr > V > Ni > Cu > Cо. The results of investigation showed that the epiphytic moss (Pylaisia polyantha) can be used as indicator of heavy metals pollution in different polluted zones
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THE ROLE OF ARCHITECTURAL PROPAEDEUTICS IN THE DEVELOPMENT OF PROFESSIONAL SKILLS OF AN ARCHITECT
DescriptionExperience of leading architectural schools and faculties of the country on the integration of propaedeutic course with fundamentals of architectural design in early stages of education is described in the article. The technique of the relationship between composition and specific design tasks, implemented in Rostov architectural school is presented here. The schemes of the phased teaching of students of architectural specialties by the example of the first three course works
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Description
Green building, forestry, agriculture of the Rostov region is in desperate need of resistant and long-lived samples of deciduous trees of the first grade. The main object of the search of promising forms of deciduous trees were artificial plantations of Quercus robur in the Botanical Garden of SFU. The research identified several of samples of Quercus robur, which are of economic interest. Based on ecological and biological properties and economic qualities, the most promising on was a sample of Quercus robur var. tardiflora, planted in 1888. This sample is less receptive to pests and diseases. It also has a high winter hardiness and drought resistance and significantly superior to similar samples of Quercus robur along longevity and has a high decorative effect. Dedicated sample of Quercus robur var. tardiflora, and his generation from seed is very different from other samples of the population by time of phenological phases. The all main henological phases of this sample occured later by on 10-15 days. The sample belongs to the group of plants of late phenological dates start and end of the growing season. The phenology of dedicated samples contributes to their high steadiness into regional climate. It propagates by sowing freshly harvested seeds. Phenological features of the selected sample might be inherited in the seminal generations
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Description
Rendzina soils are very widespread in the Caucasus. Because of their ecological and genetic characteristics Rendzina has significant buffering capacity to chemical pollution. The object of investigation was calcareous leached soil. Location selection - Azishskaya ridge on the border of the Republic of Adygea and the Krasnodar region. As pollutants, we have selected Zn, Cd, Mo, Se, since soil contamination with these elements in the south of Russia is not uncommon. Contamination of zinc, cadmium, molybdenum and selenium causes deterioration in the biological properties of calcareous soils of the Western Caucasus. We have investigated the toxicity of the elements formed following series due to their influence on Rendzina soils: Zn> Se> Cd> = Mo. The study attempted to analyze the entire range of concentrations of the examined elements in the soil, currently occurring in nature. In most cases, all the investigated substances registered direct correlation between the concentration of the pollutant in the soil and the degree of reduction of biological indicators. The activity of catalase and dehydrogenase cellulolytic ability, plenty of bacteria of the genus Azotobacter, length of roots of radish can be used to monitor, diagnose and regulation of chemical pollution of soil Zn, Cd, Mo, Se
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Description
The article reports about the results of the new population of protected herb species studying in the Rostov region and in the Russian Federation - Cymbochasma borysthenica (Pall are given. ex Schlecht.) Klok. & Zoz (Orobanchaceae), registered in 2014 on the northern coast of Mius Liman in the Rostov-on-Don Region. The new habitat is located at considerable distance from the earlier known. The population area has about 200 sq. m, total number – more than 1000 uneven-age specimens of a seed and vegetative origin. Population consists of two cenopopulations one of which lives in community of transitional type from a timyannik to a stony steppe (association: Festuca valesiaca – Cleistogenes bulgarica – Cymbochasma borysthenica – Thymus dimorphus), another – as a part of the stony steppe (association: Festuca valesiaca + Agropyron pectinatum + Galatella villosa), created at the limestone shell rock exits. Cenopopulation in community of transitional type, despite the smaller area (50 sq. m), differs by more number and density. Both cenopopulations are similar in age ranges character and vitality of specimens. They belong to a normal type (capable to vegetative and seed self-maintenance) with a left-side age range that allows estimating them as rather stable, despite very limited area
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BIO-DIAGNOSTICS OF RESISTANCE OF GREY FOREST SOILS OF ADYGEA TO POLLUTION WITH Zn, Cd, Mo, Se
DescriptionThe essential part of a soil cover of the Republic of Adygea is occupied by gray forest soils. Thus they still remain a little studied, including concerning their resistance to chemical pollution. Contamination of gray forest soils of Adygea with Zn, Cd, Mo, Se causes deterioration of their biological properties. In most cases, the degree of reduction of the values of biological indicators is directly dependent on the concentration of pollutant in the soil. According to the degree of toxicity to the biological properties of the investigated elements form the following sequence: Se > Zn > = Cd > Mo. Biological parameters investigated in research (activity of catalase and dehydrogenase, cellulolytic ability, abundance of bacteria of the genus Azotobacter, radish root length) may be used for purposes of monitoring, diagnosis and regulation of chemical pollution of gray forest soils Zn, Cd, Mo, Se
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THE OPERATED EYE HYDRODYNAMICS MATHEMATICAL MODELING FOR OPTIMIZATION OF SURGERY THECNIQUE
DescriptionAcceptable values of the drainage hole parameters in the shunt glaucoma surgery were calculated by means of mathematical modeling of different conditions of eye hydrodynamics. The operation method was designed with provision for pressure gradient, rate of the aqueous humor outflow, and the values of intraocular pressure in early and late postoperative period. The balance of liquid in eye was calculated in mathematical model as ordinary differential equation in accordance with flow resistance of every section. The data received by using mathematical model has shown that allowable rate of aqueous humor outflow is gained with the hole diameter of 0,025 mm. This mathematical model should assist to the better understanding of physical processes describing the eye hydrodynamics, should benefit to the operation quality and should create the base to the clinical studies
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THE MATHEMATICALLY BASED CHOISE OF VISCOELASTIC IN SHUNT GLAUCOMA SURGERY
DescriptionThe dramatic lowering of intraocular pressure (hypotony) is developing during glaucomatous surgery due to the formation of the new aqueous humor outflow. The calculations of the flow in the fluid balance parameters have shown, that for the normal intraocular pressure maintenance in the postoperative period the fluid flow out of the anterior chamber should not exceed 0,04 microliter in minute. The intensity of the aqueous humor outflow through the shunts with different parameters does not depend on the shunt length. The shunt with the inner hole radius 0,025 mm is the most safe as it provide the less outflow. The experimental comparative study of the static viscosity of the most widely used viscoelastics in ophthalmological surgery was carried out. It was stated that used in eye surgery viscoelastics on the basis of 1%, 2% and 3% sodium hyaluronate possess the viscosity, that differs in 10 and 100 times and has significant influence on the flow intensity out of the anterior chamber when the new outflow tracts are formed. The mathematically based choice of the most optimal relationship between the viscoelastics physical parameters and the inner hole size of the shunt type glaucoma drainage devices was established. Shunt with the inner hole radius 0,05 mm and simultaneous use of 2% and 3% sodium hyaluronate solution is the most safe for the maintenance of the eye tonus during the first 5 days after glaucoma surgery. The presented correlation allows to increase the safety of the surgical treatment of the patients with the refractory glaucoma
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THE MATHEMATICALLY BASED CHOISE OF VISCOELASTIC IN SHUNT GLAUCOMA SURGERY
DescriptionThe dramatic lowering of intraocular pressure (hypotony) is developing during glaucomatous surgery due to the formation of the new aqueous humor outflow. The calculations of the flow in the fluid balance parameters have shown, that for the normal intraocular pressure maintenance in the postoperative period the fluid flow out of the anterior chamber should not exceed 0,04 microliter in minute. The intensity of the aqueous humor outflow through the shunts with different parameters does not depend on the shunt length. The shunt with the inner hole radius 0,025 mm is the most safe as it provide the less outflow. The experimental comparative study of the static viscosity of the most widely used viscoelastics in ophthalmological surgery was carried out. It was stated that used in eye surgery viscoelastics on the basis of 1%, 2% and 3% sodium hyaluronate possess the viscosity, that differs in 10 and 100 times and has significant influence on the flow intensity out of the anterior chamber when the new outflow tracts are formed. The mathematically based choice of the most optimal relationship between the viscoelastics physical parameters and the inner hole size of the shunt type glaucoma drainage devices was established. Shunt with the inner hole radius 0,05 mm and simultaneous use of 2% and 3% sodium hyaluronate solution is the most safe for the maintenance of the eye tonus during the first 5 days after glaucoma surgery. The presented correlation allows to increase the safety of the surgical treatment of the patients with the refractory glaucoma